Temporal integration by a slowly inactivating K+ current in hippocampal neurons
نویسندگان
چکیده
منابع مشابه
Pharmacology of a slowly inactivating outward current in hippocampal CA3 pyramidal neurons.
The pharmacology of a slowly inactivating outward current was examined using whole cell patch-clamp recordings in CA3 pyramidal cells of guinea pig hippocampal slices. The current had a low activation threshold (about -60 mV) and inactivated slowly (time constant of 3.4 +/- 0.5 s at -50 mV) and completely at membrane voltages depolarized to -50 mV. The slowly inactivating outward current was ma...
متن کاملSlowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons.
The properties of voltage-gated ion channels on the neuronal membrane shape electrical activity such as generation and backpropagation of action potentials, initiation of dendritic spikes, and integration of synaptic inputs. Subthreshold currents mediated by sodium channels are of interest because of their activation near rest, slow inactivation kinetics, and consequent effects on excitability....
متن کاملModulation of a slowly inactivating potassium current, I(D), by metabotropic glutamate receptor activation in cultured hippocampal pyramidal neurons.
I(D) is a slowly inactivating 4-aminopyridine (4-AP)-sensitive potassium current of hippocampal pyramidal neurons and other CNS neurons. Although I(D) exerts multifaceted influence on CNS excitability, whether I(D) is subject to modulation by neurotransmitters or neurohormones has not been clear. We report here that one prominent effect of metabotropic glutamate receptor (mGluR) activation by s...
متن کاملSelective control of cortical axonal spikes by a slowly inactivating K+ current.
Neurons are flexible electrophysiological entities in which the distribution and properties of ionic channels control their behaviors. Through simultaneous somatic and axonal whole-cell recording of layer 5 pyramidal cells, we demonstrate a remarkable differential expression of slowly inactivating K(+) currents. Depolarizing the axon, but not the soma, rapidly activated a low-threshold, slowly ...
متن کاملSlowly inactivating component of Na + current in the peri - somatic region 2 of hippocampal CA 1 pyramidal neurons 3
36 37 The properties of voltage-gated ion channels on the neuronal membrane shape electrical 38 activity such as generation and back-propagation of action potentials, initiation of 39 dendritic spikes, and integration of synaptic inputs. Subthreshold currents mediated by 40 sodium channels are of interest because of their activation near rest, slow inactivation 41 kinetics, and consequent effec...
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ژورنال
عنوان ژورنال: Nature
سال: 1988
ISSN: 0028-0836,1476-4687
DOI: 10.1038/336698b0